Author: Abdel-Karim, Mohamed Selim./ Title: Possible Association between the Transforming Growth Factor Beta-1 Polymorphisms and Idiopathic Carpal Tunnel Syndrome in Egyptian patients /

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العنوان

Possible Association between the Transforming Growth Factor Beta-1 Polymorphisms and Idiopathic Carpal Tunnel Syndrome in Egyptian patients /

المؤلف

Abdel-Karim, Mohamed Selim.

هيئة الاعداد

باحث / Mohamed Selim Abdel-Karim

مشرف / Noha M. Mesbah

مشرف / Asmaa R. Abdel-Hamed

مناقش / Maivel hehmat ghattas

الموضوع

Beta. Carpal Tunnel Syndrome.

تاريخ النشر

2023.

عدد الصفحات

107 P. :

اللغة

الإنجليزية

الدرجة

ماجستير

التخصص

الصيدلة ، علم السموم والصيدلانيات (المتنوعة)

تاريخ الإجازة

11/9/2023

مكان الإجازة

جامعة قناة السويس - كلية الصيدلة - الكيمياء الحيويه

الفهرس

Only 14 pages are availabe for public view

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107

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Abstract

The study aimed to investigate the possible genetic association of transforming growth factor-
β1 (TGF-β1) +915G/C, -509C/T and -800G/A single nucleotide polymorphisms (SNPs) and
MIP-1β protein with idiopathic carpal tunnel syndrome (CTS). CTS patients showed increased
serum levels of TGF-β1 and macrophage inflammatory protein-1β (MIP-1β). Minor alleles of
both TGF-β1 rs1800471 (+915G/C) and rs1800469 (-509C/T) polymorphisms were associated
with CTS. Also, these alleles were associated with TGF-β1 and MIP-1β overproduction. Major
allele of rs1800468 (-800G/A) polymorphism showed an association with CTS. Moreover, this
major allele was associated with increased TGF-β1 and MIP-1β serum levels.