الفهرس | Only 14 pages are availabe for public view |
Abstract Myocardial infarction continues to be a major public health problem worldwide. During myocardial ischemia, acute inflammation, and tissue damage serotonin accumulates in the myocardial interstitium and plays an important role in the progression of myocardial cellular injury. Flibanserin, a drug approved for treatment of hypoactive sexual desire disorder has a high affinity for serotonin receptors, causing both a decrease in serotonin release and an inhibition of specific serotonin receptors involved in myocardial ischemia/infarction. The present study aimed to investigate the potential cardioprotective effect of flibanserin on isoproterenol induced myocardial infarction in female rats. Flibanserin in a dose dependent manner successfully improved electrocardiogram findings, cardiac and oxidative stress markers, calcium overload, serotonin release, 5-HT2A receptors gene expression, and histopathological and hypertrophic manifestations of isoproterenol induced myocardial infarction. Keywords: Flibanserin; Isoproterenol; Myocardial infarction; cardioprotection; 5-HT2A receptors; rats. |