الفهرس 
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Abstract
Pyranoquinolinones were synthesized then exposed to nitration proceeding to get nitro derivatives which underwent a reduction process to afford 3-aminopyrano[3,2-c]quinoline-2,5-diones. A novel series of brominated N-alkyl pyrano[3,2-c]quinoline-2,5-diones were developed as well. The structures of this series were authorized via elemental analysis, spectroscopic and spectrometry analysis. The antiproliferative activity for these compounds towards different cancer cell lines were tested. Likewise, a new series of heterocyclic systems were produced bearing pyrano[3,2-c]quinolinones and pyrazolone moieties. The latter compounds were used to prepare different Schiff bases and hydrazone analogues. They were evaluated for their anticancer activities for some human cancer cell lines (A-549, HCT-116, and MCF-7).
Keywords: Pyranoquiolinones, Bromo, Schiff bases, Pyrazolone, Antitumor activity.