الفهرس 
? THALASSEMIAOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: Beta-thalassemia syndromes are a group of hereditary blood disorders characterized by reduced or absent beta globin chain synthesis, resulting in reduced Hb in red blood cells (RBC), decreased RBC production and anemia. Cardiovascular complications in patients with beta thalassemia such as cardiomyopathy and arrhythmia are considered the most common cause of death in those patients. Cystatin C is a popular marker of nephropathy in sickle cell disease and beta thalassemia that has been recently used for prediction of subclinical cardiovascular dysfunction in patients with or without renal affection.
Aim of the work: This study aimed to assess the role of serum cystatin C in adult patients with beta thalassemia as a predictor of subclinical cardiovascular dysfunction.
Patients and methods: The study was a case control study including 50 beta thalassemia patients and 50 age and sex matched healthy controls. Serum cystatin c was assessed by ELISA in both patients and controls.
Conclusion: There was statistically significant correlation between the level of serum cystatin C and cardiovascular dysfunction in thalassemic patients making serum cystatin C an encouraging factor for the prediction of subclinical cardiovascular dysfunction in beta thalassemia patients.