الفهرس | Only 14 pages are availabe for public view |
Abstract Abstract Heavy metals, including arsenic, cadmium, chromium, copper, lead, nickel, and zinc, pose risks to both human health and the environment. Zinc and copper are essential trace elements crucial for proper neuronal functioning, and disturbances in their metabolism are implicated in various brain disorders, including autism. Brain-specific autoantibodies, including those targeting myelin-basic protein, have been found in children with autism, suggesting a potential connection between heavy metals, autoimmune reactions, and the development of autism spectrum disorders. The exact mechanisms behind the formation of brain-specific autoantibodies in autism remain unclear, but environmental factors such as heavy metals are speculated to trigger autoimmune reactions to neurons. This study has a dual objective: firstly, to investigate the correlation between anti-myelin-basic protein (MBP) brain-specific antibodies and zinc and copper levels in children with autism, shedding light on potential immunological and metal-related factors in autism spectrum disorders. Secondly, the research aims to examine how these correlations relate to the severity of autism. |