الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Obesity is a risk factor for breast cancer. The exact mechanisms by which obesity increases the risk of breast cancer are not fully understood, but several factors are thought to play a role in promoting breast cancer growth and progression. These include increased aromatase-mediated estrogen production, high-circulating insulin/insulin-like growth factor I (IGF-I) and altered adipokine concentrations and their signaling pathways which collectively promote a chronic inflammatory condition.
The clinicopathologic and prognostic significance of body mass index (BMI) in breast cancer patients remained conflicting. Limited data are available regarding the impact of obesity on pathologic features of breast cancer and/or outcomes.
In this retrospective cohort study, we aimed to investigate the impact of obesity on clinicopathological features and prognosis of breast cancer patients.
Breast cancer patients, attending Clinical Oncology and Nuclear medicine department in Suez Canal University hospital, in period between January 2013 till December 2018 and fulfilling the Inclusion Criteria and exclusion criteria were enrolled. They were stratified into three groups according to body mass index (BMI) as following:
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group A: normal weight patients (patients with BMI = 18.5 – 24.9 kg/m2).
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group B: overweight patients (patients with BMI = 25 – 29.9 kg/m2).
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group C: obese patients: (patients with BMI ≥ 30 kg/m2) .
Using clinical data in medical records. We compared groups regarding clinicopathological variables, the disease-free survival (DFS) and 10-year overall survival between them.
273 breast cancer patients were included, 27 were normal weight patients, were 58 overweight patients and 188 were obese patients.
It found that obese patients were more likely to be older at diagnosis (mean age at diagnosis = 50 years) and postmenopausal (61.7 % of obese patients).
Overweight and