الفهرس | Only 14 pages are availabe for public view |
Abstract Recently, many studies established a relationship between Parkinson’s disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, patients with T2DM appear to be at a higher risk of acquiring Parkinson’s disease, as well as experiencing faster development and a more severe phenotype, with the effects possibly mediated by numerous common cellular mechanisms. For example, the insulin signaling system may contribute to neurodegeneration through insulin dysregulation, amyloid accumulation, neuroinflammation, and mitochondrial dysfunction. Intermittent fasting (IF) with its various forms proved to have many benefits on human body health. IF leads to shifting the body from the utilization of glucose to fatty acids and ketones. This transition is responsible for the shift from the production and accumulation of lipids to the release of fat as free fatty acids and ketone molecules. that occur in the body. This metabolic reprogramming has been identified as a potential basis for many of the positive effects of IF, including improved glucose homeostasis and DNA repair. IF also promotes autophagy, stem cell renewal, and stress resistance, and inhibits inflammation. Both IF and metformin have neuroprotective effects through their ability to attenuate oxidative stress and improve mitochondrial dysfunction and neurogenesis. The present study was conducted on 75 adult male albino rats of local strain, with an average body weight of 180 g, ranging from 150 to 200 g. They were left for one week of acclimatization to lab conditions before the start of the experiment. Rats were fed a standard diet of commercial rat chow during the week of accommodation and tap water ad libitum. |