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Abstract Renal transplantation (RT) represents the preferred and optimal treatment modality for patients with ESKD, offering longevity and quality of life advantages over dialysis. Advances in surgical techniques, immunosuppression, and post-transplant care have enabled the expansion and success of kidney transplantation over the years. Older age alone is no longer considered an absolute contraindication to transplantation. However, elderly ESKD patients represent a unique clinical population characterized by a complex interplay of medical conditions and varying degrees of frailty. This poses significant challenges for kidney transplantation, requiring a comprehensive understanding of the specific risks and considerations associated with this patient group. Moreover, additional barriers to elderly RT are the lack of well-defined selection criteria for elderly RTRs, donor shortage, and uncertain clinical outcomes. This retrospective cohort study was conducted to evaluate renal transplant outcomes in RTR aged ≥ 60 years, regarding patient survival, graft survival, and de novo morbidities as compared to younger recipients. The study also aimed to determine the possible association of pre- and post-transplant recipient-related risk factors, and donor characteristics with transplant clinical outcomes, as well as defining predictors for optimal patient selection and RT outcomes in elderly RTR. |