الفهرس 
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Abstract
Atopicdermatitis(AD),alsoknownasatopiceczema,isachronicrelapsinginflammatoryskincondition.. IL-37hasbeenidentifiedasfundamentalinhibitorofinnateimmunityandasuppressorofproinflammatorycytokinessuchasIL-1,IL-6,IL-8,IL-17,IL-23,andTNF-α,andIFN-γ.
TheaimofthepresentstudywastoassessthealterationofserumlevelofIL-37inADpatientswhichmayfurtherclarifytheimmunepathogenesisandimprovethemanagementofthiscommonimportantskindisease.
Thisstudyisacasecontrolstudy,That wascarriedinDermatologyOutpatientClinicofSuezCanalUniversityHospitals,Ismailia,andincluded2groups:(Firstgroup);includedpatientswhohadatopicdermatitis,(Secondgroup);includedhealthyageandgendermatchedcontrolswithoutanyfamilyhistoryorprevioushistoryofclinicalatopysymptoms.SeverityofADwasevaluatedusingSCORAD.Bloodsampleswereexaminedtodetect:CBCwithdifferential,serumIgEandserumconcentrationsofIL-37viaELISAkitsforquantitativeanalysisofIL-37.
Inthisstudy,mostofthepatients(92.5%)hadseverAD,7.5%ofthepatientshadmoderateAD.SerumlevelsofIL37weresignificantlyhigherinADpatientsthaninhealthycontrols,andthislevelcorrelatedpositivelywitheachofSCORADandIgEandcorrelatednegativelywithpatients’ageandageofdiseaseonset