الفهرس 
INTRODUCTION & AIM OF WORKOnly 14 pages are availabe for public view
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Abstract
Antimicrobial resistance poses considerable issues for current clinical care, so the modified use of antimicrobial agents and public health initiatives, coupled with new antimicrobial approaches, may help to minimize the impact of multidrug-resistant (MDR) bacteria in the future.
Aim, The dramatic increase in resistance of XDR P. aeruginosa and S. aureus to antimicrobial drugs has accelerated the interest in the development of new therapeutics to aid in prevention and treatment of live threatening infections caused by these strains. Herein, in vitro and in vivo evaluation of the antimicrobial, antioxidant, and immunomodulatory potentials of Lagenaria siceraria, Thymus vulgaris plant extracts and their combination with chitosan nanoparticles and also Phoenix dactylifera and Withania somnifera ethanolic extracts were performed that may serve as basic structures for the development of novel therapy against the extensive drug-resistant (XDR) P. aeruginosa and VRSA. To achieve the above mentioned aim,
In conclusion, Summing our observation, it could be concluded from the obtained results that Lagenaria siceraria and Thymus vulgaris oils or their chitosan loaded nanoparticles have antibacterial activity against P. aeruginosa and VRSA.Therefore , it could be advised to use these oils and their chitosan loaded nanoparticles as a novo structure for the development of a promising antibacterial therapy against P. aeruginosa and VRSA to avoid the problems of antibiotic resistance.