الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hyperthyroidism, characterized by an overactive thyroid gland, is associated
with severe complications such as liver dysfunction, dyslipidemia, diabetes,
insulin resistance, cardiovascular disorders, neurological complications, and
cognitive impairment. This study aimed to explore the potential therapeutic
effects of rutin and aescin in male rats with hyperthyroidism induced by Lthyroxine. Fifty-six male albino rats were divided into negative control ( Rats
were received only distilled water for 50 days) and hyperthyroid induced
groups. Hyperthyroidism was induced by the orally given L- thyroxine (240
μg/kg) for 20 days. Then hyperthyroidism checked groups were divided into
six groups, hyperthyroid, HT + PTU, HT + Rutin, HT + Aescin, HT + PTU
+ Rutin and HT + PTU + Aescin. The study revealed that L-thyroxine
administration induced hyperthyroidism-associated complications, including
hepatic toxicity, dyslipidemia, hyper- glycemia, insulin resistance, cardiac
damage, and neurotoxic effects. Treatment with rutin and aescin
demonstrated promising cytoprotective effects, mitigating liver damage,
dyslipidemia, hyperglycemia, insulin resistance, and neurological disorders
induced by hyperthyroidism. Histological examination supported these
findings, showing significant improvements in liver and heart tissues. The
study concludes that rutin and aescin could be valuable strategies to alleviate
oxidative stress and inflammation associated with hyperthyroidism-induced
complications.