الفهرس 
Aim of the StudyOnly 14 pages are availabe for public view
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Abstract
Benign prostatic hyperplasia (BPH) is a frequent cause of LUTS in
men. Both active and passive forces in the prostate tissue have a role in the
pathophysiology of BPH.
The adrenergic nervous system has been reported to regulate active
smooth muscle tone.
Alpha1-blockers inhibit contraction of smooth muscle in the prostate
and reduce prostate tone and BOO.
Alpha -blockers are the drugs of choice for LUTS secondary to BPH.
Alpha 1-adrenoceptors are divided into three subtypes α 1a, α 1b,
and α 1d.
The current study evaluated the efficacy and safety of single versus
double dose of tamsulosin 0.4 mg for treatments of moderate and severe
LUTS/BPH and effect on IPSS, Uroflowmetry and PVR at 3 times
intervals.
Total IPSS was more decreased (improved) in double dose
tamsulosin 0.4 mg group than single dose tamsulosin 0.4 mg group, with
P-value = 0.005 at one month follow up and 0.007 at three months follow
up, which is statistically significant difference.
Dizziness was more frequent in double dose tamsulosin 0.4 mg
group than single dose tamsulosin 0.4 mg group, with P-value = 0.03 at one
month follow up and 0.01 at three months follow up, which is statistically
significant difference.