الفهرس 
Acute kidney injury in neonatesOnly 14 pages are availabe for public view
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Abstract
Acute kidney injury (AKI) is a complex disorder (AKI) means the
sudden loss of kidney function generally occurring over the course of hours
to days and resulting in the retention of metabolic waste products and
dysregulation of fluid, electrolyte, and acid-based homeostasis. Acute
kidney injury (AKI) is common in critically ill premature neonates.
Serum creatinine in the first few days of the neonate’s life reflects
the mother’s and not the infant’s renal function. Novel urinary biomarkers
can diagnose acute kidney injury within hours of an insult have been
discovered.
Plasma creatinine has many limitations as diagnosis is often delayed
and imprecise in the setting of critical illness. Biomarkers of AKI are
heterogeneous molecules. Some appear to be produced directly within the
kidney as a result of tubular injury or stress urinary neutrophil gelatinaseassociated lipocalin (NGAL) others may appear in the urine due to failure
of proximal tubular uptake such as urinary cystatin c, while others again
may simply be more precise markers of alteration in glomerular filtration
rate (serum cystatin c – CysC), and interleukin 18.
Glutathione S-transferase (GST) isoenzymes catalyze the
conjugation of reduced glutathione and exhibit other GST-dependent
catalytic activities including the reduction of organic hydroperoxide and
isomerization of various unsaturated compounds.
Glutathione S-transferase is in proximal tubules and Bowman’s
capsule before the 35th week of gestation, and only after this gestational
week does it get found in distal tubules. That is why, the releasing of
Glutathione S-transferase from damaged proximal tubules occurs in
prematurely born neonates. The level of serum GST could be an estimated glomerular filtration rate-independent factor involved in kidney damage.
So, the aim of this study was to assess the role of serum glutathione Stransferase (GST) for early detection of acute kidney AKI in neonates.
To elucidate our aim, this prospective study was carried out on 83
neonates admitted into NICU of Menoufia University hospital to study
glutathione S-transferase as a predictor of acute kidney injury during a
period time from November 2019 to February 2021.