الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Bone defects frequently arise as a result of trauma, tumor removal, congenital abnormalities, osteoporotic fractures, surgery, and autologous bone transplants are still widely regarded as the most effective method for reconstructing large bone defects. Nevertheless, the negative impact on the patient’s health caused by the process is still a disadvantage that has prompted the advancement of novel technical methods to enhance the effectiveness of the treatment.
Tissue engineering and regenerative medicine (TERM) employ stem cells to address a wide range of challenging disorders. This approach offers advantages such as shorter hospital stays, decreased morbidity, and lower immunological responses. The production of high-quality tissue engineering constructions relies on three fundamental components: suitable scaffolds for facilitating tissue-cell regeneration, cytokines, and adequate seed cells. Moreover, each of them must exhibit a multitude of properties and characteristics that render them well-suited for this objective.
Uniform human dental pulp stem cells (hDPSCs) with specific mesenchymal stem cell (MSC) properties and platelet-rich plasma (PRP) were transplanted into the surgery site utilizing a HA/PLGA scaffold in the present study. In vitro evaluation of osteogenic differentiation was carried out using Alizarin red and Von Kossa staining techniques. In addition, we studied the effects of HA/PLGA/DPSCs and HA/PLGA/PRP on bone regeneration in rabbits with large mandibular lesions for about three months.