الفهرس 
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Abstract
Introduction: Oral lichen planus (OLP) is a chronic immune-mediated disease that affects the oral cavity with variable clinical presentations. Corticosteroids had been proven to be effective in treating OLP, but give undesirable side effects so there is still an imperative need for searching about other treatment modalities with comparable efficacy and fewer unfavorable impacts. Objectives: To evaluate the efficacy of topical application of mucoadhesive mycophenolate mofetil (MMF) and intra-lesional injection of platelet rich fibrin (i- PRF) in the treatment of symptomatic oral lichen planus. Materials and methods: 30 patients with symptomatic OLP were randomly assigned into 3 groups, each group included 10 patients. GroupІ (GI): were managed by bilateral intralesional injections with autologous i-PRF* weekly for 6 weeks. GroupӀӀ (GII): were managed by topical MMF** gel twice daily for 6 weeks. GroupӀӀӀ (GIII): were managed by bilateral intralesional injections with triamcinolone acetonide (TA)*** weekly for 6 weeks. Assessment was done clinically via calculating the changes in the lesion size, the severity of pain and burning sensation. Immunologically via measuring the amount of tumor necrosis factor-alpha (TNF-α) in saliva. Clinical parameters were recorded, at base line then every two weeks for two months, samples collections for immunologic test were collected at baseline, 4week and 8 week. Results: For the three groups all clinical and immunological parameters showed significant improvement along the study periods, where significant reduction of lesion size and lowering of the pain score and decrease in the amount of TNF-α in saliva samples were found from the base line through all measuring point of time to the end of the study. Regarding the intergroup comparison: At base line, no significant deference was observed between the three groups. However, the clinical and immunological amelioration was in favor of the GI compared to the other two groups. Comparing GII and GIII the preference was in favor of GIII. Conclusions: I-PRF can be used as an effective and safe treatment remedies for OLP gives superior improvement clinically and immunologically compared to corticosteroids and MMF. Topical MMF gel can be used as effective modality with reasonable improvement.