الفهرس 
Incidence and prevalenceOnly 14 pages are availabe for public view
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Abstract
A viral wart is a very common benign lesion caused by infection with human papillomavirus (HPV). No one treatment is an absolute cure for warts. Currently, there are many treatment options available, either focus on physical or chemical tissue destruction that often lead to recurrence. Immunotherapy is promising as it decreases the likelihood of wart recurrence. Vitamin D controls cell proliferation and differentiation and has immunoregulatory activities. Its effects are mediated via the vitamin D receptor (VDR), which is present in keratinocytes, melanocytes, fibroblasts and immune system cells of the skin. Methotrexate (MTX) is an antiproliferative, anti-inflammatory and immuno-modulating agent. MTX inhibits double stranded nucleic acid (DNA) synthesis in actively dividing cells. MTX has antiviral effect through inhibition of dihydrofolate reductase.