الفهرس 
Introduction and BackgroundOnly 14 pages are availabe for public view
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Abstract
Diabetes and obesity are chronic disorders that are on the rise worldwide. Body mass index has a strong relationship to diabetes and insulin resistance. In an obese individual, the amount of NEFA, glycerol, hormones, cytokines, proinflammatory substances, and other substances that are involved in the development of insulin resistance are increased. Insulin resistance with impairment of β-cell function leads to the development of diabetes. Gaining weight in early life is associated with the development of type 1 diabetes. NEFA is a cornerstone in the development of insulin resistance and in the impairment of β-cell function. New approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on these facts.
In summary, overweight and obesity are strongly linked to the development of type 2 diabetes and can complicate its management. Obesity is also an independent risk factor for hypertension and dyslipidemia as well as for cardiovascular disease, which is the major cause of death in persons with diabetes. Moderate weight loss improves glycemic control, reduces cardiovascular disease risk, and can prevent the development of type 2 diabetesand can prevent the development of type 2 diabetes in persons with prediabetes. Therefore, weight loss is an important therapeutic strategy in all overweight or obese persons with type 2 diabetes or who are at risk of developing diabetes.