الفهرس 
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Abstract
P
soriasis is one of the most common inflammatory skin diseases and affects approximately 1–3% of the general population worldwide. Although psoriasis is more prevalent in men, it was previously shown to be more frequent and severe in women than in men.
Psoriasis vulgaris (PVs) is a chronic immune-related skin disorder substantially detrimental to patients’ QOL characterized by complex alterations in epidermal growth and differentiation, as well as multiple biochemical, immunologic, and vascular abnormalities. The pathogenesis of this disease is linked to many interactive responses among infiltrating white blood cells, dendritic cells, proinflammatory cytokines, chemokines, and chemical mediators produced in the skin. Additionally, PVs has been introduced as a possible a systemic entity related to cardiovascular, endocrine, metabolic, gastrointestinal, renal, and consequentially psychological conditions such as depression and anxiety. Skin dendritic cell activation and IL-23 mediated induction of Th17 signaling is the primary pathophysiology of PVs.
The aim of the study is to evaluate the possible relationship between the level of the proinflammatory cytokine TSLP and the development of itch in psoriatic patients via assessment of the tissue levels of Thymic Stromal Lymphopoietin in psoriatic patients by ELISA.
This is a case-control study, the study was conducted in Dermatology, Venereology, and Andrology department, Ain-Shams University Hospitals from September 2022 to May 2023. The study included 90 participants, recruited by consecutive sampling, and categorized into three groups: group 1: 30 patients having psoriasis with itching, group 2: 30 patients having psoriasis without itching, group 3: 30 normal healthy controls.
Although we found that TSLP was elevated in psoriatic lesions compared to healthy control skin; yet this elevation was irrespective to the presence of itching, as both psoriasis groups, psoriasis with and without itching, had higher levels of tissue TSLP but with no significant difference in between. However, we found that TSLP had no relation to the presence of itch incidence in psoriasis patients. On the contrary, TSLP was expressed in psoriasis lesions irrespective of itch occurrence or psoriasis severity. So, we can thus implicate that itching in psoriatic skin is likely to be mediated by cytokines and factors other than TSLP and the rise in TSLP levels found in psoriatic lesion was likely to be linked to its role in the pathogenesis of the disease itself rather than its role in mediating the itch symptom. However, further studies on the relation of serum TSLP to itching in psoriasis would be beneficial.
We concluded that, lesional TSLP was higher in psoriasis patients compared to healthy controls with no relation between psoriasis severity and presence of itching, and both; severity of psoriasis and itching were associated with more impairment of quality of life.