الفهرس 
BronchitisOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory condition characterized by persistent airflow limitation and is a leading cause of morbidity and mortality worldwide. Acute exacerbations of COPD (AECOPD) represent sudden and often severe worsening of symptoms, leading to increased breathlessness, coughing, and sputum production. These exacerbations significantly contribute to the overall burden of the disease and are associated with a decline in lung function, impaired quality of life, and increased healthcare utilization.
Objective: To examine the role of blood markers, including eosinophil count, neutrophil count, and C-reactive protein (CRP), in the severity and prognosis of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Patients and Methods: This is a prospective cohort study was conducted at Intensive Care Department, Ain Shams hospitals during the period from January 2021 to November 2023. The current study included patients diagnosed with COPD According to GOLD criteria and experiencing an acute exacerbation (defined as an increase in symptoms requiring additional medical intervention).
Results: The study also identified significant differences in the severity of chronic obstructive pulmonary disease (COPD) between the two groups (p=0.002), with group B showing a significantly increased severity compared to group A. Regarding 30-day mortality, there were no significant differences observed between group A and group B (p>0.05). The study provides valuable insights into the association between laboratory measurements, clinical outcomes, and management strategies in acute exacerbations of COPD, highlighting the importance of considering these factors in the assessment and treatment of patients with AECOPD.
Conclusion: Our study offers valuable insights into the multifaceted relationship between blood markers, clinical outcomes, and management strategies in the complex landscape of acute exacerbations of COPD.