الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Current study aimed to investigate whether there is strong association between higher ΔP and mortality among ventilated patients with ARDS, and if this was modified by clinical characteristics of several subgroups based on ARDS severity (mild, moderate and severe), and ΔP cutoff value (>14 vs.≤14), Also its role to predict prognosis among different ventilatory variables To attain these objectives 120 ARDS patients were admitted to Assiut RICU during the period from October 2021 to January 2023 and needed ventilatory support. Out of them 50 ARDS patients fulfilled the inclusion criteria and underwent invasive mechanical ventilation(IMV) with protective lung strategy(PLS) and met the inclusion criteria of current study Current study assessed the risk of hospital mortality (30 day mortality) based on assessment different ventilatory variables: ΔP, tidal volume (TV), positive end-expiratory pressure (PEEP), plateau pressure (Pplat), respiratory system compliance (Crs) and mechanical power (MP) evaluated at 24 hours after acute respiratory distress syndrome diagnosis while ventilated with standardized lung-protective ventilationThe following results were observed Regarding demographic data of 50 ARDS patients MV with PLS among survivors and non-survivors, neither continuous neuromuscular blocker (NMBA) nor (mCXR) score of affected radiological areas were associated with significant effect on 30-day mortality while high serum lactate was associated with increased mortality. PaCO 2 was higher in non-survivors compared to survivors. Also higher values of SAPSII score and corresponding predicted mortality were associated with increased mortality and ventilation/perfusion (P/F) ratio was significantly higher in survivors compared to non survivors. While assessing respiratory variables on day 1 mechanical ventilation among survivors and non survivors: lower ΔP was strongly associated with improved survival. Also, lower Pplat and lower MP were associated with better survival. while lower Crs and lower PEEP was associated with increased mortality but neither (RR) nor (TV) showed significant statistical difference, between survivors and non survivors ROC curves were plotted among the studied ARDS patients and revealed that: >14 cmH2O, >25 cmH2O and 17 J/minute were significant cut off values for ΔP, Pplat, and MP respectively with high accuracy, sensitivity and specificity to predict mortality.