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Abstract Preterm birth has a significant morbidity and mortality on the new born. The severity of these effects increases the more premature the delivery is. Approximately, 50% of all perinatal deaths are caused by preterm delivery, with those surviving often suffering from afflictions, caused by the birth. We performed this study to find out the long term effects of tocolysis using Nifedipine on maternal uterine and placental and fetal cerebral blood flow. This prospective, follow-up study was conducted in Emergency and inpatient wards of Obstetrics and Gynecology Department of Suez Canal university hospital on 40 pregnant women attending to Emergency ward of Obstetrics and Gynecology Department of Suez Canal university hospital by convenience sampling method and diagnosed aspreterm labor. Age ranged from 20 years to 33 years with a mean of 27.33 ± 3.53 years in the study group . The baseline measurements regarding systolic blood pressure, diastolic blood pressure, and heart rate showed insignificant differences among the study group before and after treatment. Regarding maternal uterine artery results the UtA-RI has increased significantly after 24 h of nifedipine administration and decreased after 48 hrs and one week withstatistical significant difference (p=0.006 and 0.005, respectively). UtA-PI has increased significantly after 24 h of nifedipine administration and decreased after 48 h and one week in right and left sides with statistical insignificant difference (p=0.082 and 0.231, respectively |