الفهرس 
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Abstract
Uterine Leiomyomas, also called fibroids, are the most common
benign gynecological tumor in premenopausal women . The economic
impact of leiomyomas is profound. In Egypt, affecting from 9.8% to
17.8% in the age group of 40–49 years, and about 25 % of them
underwent hysterectomy due to uterine fibroids (El-Hakim et al., 2022;
Stewart et al., 2016).
The pathogenesis of leiomyomas is still not well understood.
However, Genetic predisposition has an obvious role in their
pathogenesis. Analysis of single-nucleotide polymorphisms (SNPs) have
been shown to be a possibility to identify gene associated diseases and
could add to the knowledge of the development and progress of various
neoplasms. Generally, polymorphisms are not directly linked to a certain
disease and are therefore useful tools to study multi-factorial disorders
such as uterine leiomyomata (Chen et al., 2011).
Vascular endothelial growth factor (VEGF) plays a role in normal
physiological functions such as bone formation, hematopoiesis, wound
healing, and development. Angiogenesis is the main feature of benign and
malignant tumours. VEGF is one of the most powerful endothelial cell
mitogen and has a very critical role in normal physiological and tumor
angiogenesis . It enhances tumour vessel permeability and endothelial cell
proliferation, migration, differentiation, capillary formation and also has
proinflammatory actions (Duffy et al., 2013).
Several previous studies have reported the association between
Interleukin-1b (IL-1b-511) and several diseases as atherosclerosis,
rheumatoid arthritis, peritonitis and bowel disease (Church et al., 2008).