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Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that currently affects nearly 2% of the population in industrialized countries. The risk of AD increases dramatically in individuals beyond the age of 70 and it is predicted that its incidence will increase threefold within the next 50 years. It was well documented that bitter taste receptor agonists (caffeine and extracts of myrrh and Boswellia serrata) have antioxidant, anti-inflammatory, and anti-apoptotic potentials. This protective effect could be attributed to their contents of phytochemicals. Therefore, this study was conducted to investigate the effect of bitter taste receptor (T2R) agonists (caffeine and extracts of myrrh and Boswellia serrata) on amyloid beta (Aβ)-induced AD in rats.All deteriorated effects of Aβ were restored following treatment with caffeine (20mg/kg), myrrh aqueous extract (10 mg/kg), and Boswellia serrata aqueous extract (400 mg/kg) with best effect for myrrh aqueous extract as we previously explained. Although our work contributes to the development of therapeutics for AD by expanding our knowledge of how bitter taste receptor agonists can protect against Aβ -induced neurodegeneration, further investigations are required to give more details regarding the underlying mechanism of bitter taste receptor agonists action to protect neurons from damage by Aβ in AD. |