الفهرس 
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Abstract
The thesis is devoted to the application of metal complexation in the field of pharmaceutical analysis. Several pharmaceutical compounds belonging to different pharmaceutical groups have been determined through this approach, viz. : the antimicrobials 4-quinolones (norfloxacin, ciprofloxacin and sparfloxacin), 8-hydroxyquinoline derivatives (colioquinol and iodoquinol) and the antihypertensive captopril. The thesis is divided into seven parts :Part I : is an introductory chapter dealing with the definition, classification, uses and application of complex formation.Part II : is devoted to the polarographic analysis of some 4-quinolone derivatives through the formation of their Ni(II)-complexes.Part III : in this part an alternative technique was utilized for the same compounds, Cu(II) was used instead of Ni(II) and the compounds were determined adopting UV-derivative spectrophotometry.Part IV :This part is divided into 2 subparts :Part IV.A : deals with the UV-derivative spectrophotometric analysis of some 8-hydroxyquinolines via their Pd(II) complex formation.Part IV.B : In this part a simultaneous UV –derivative spectrophotometric method was applied to the analysis of binary mixture of iodoquinol and metronidazole in their tablets.Part V : Alternatively, an HPLC method was applied to the determination of 8-hydroxyquinoline derivatives through their Pd(II) complexes.Part VI : The same technique (Precolumn derivatization with Pd(II) / HPLC) was adopted for the analysis of captopril in pure form and tablet formulations either in single dosage forms or co-formulated with hydrochlorothiazide Part VII : Appendices including all the reagents, materials, instruments used in this thesis in addition to the procedures adopted for analysis of pure drugs, their formulations and in spiked human biological fluids.