الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The present work aims to clarify the role calcium channel blocker (verapamil), angiotensinconverting enzyme inhibitor (lisinopril), and antioxidant (ascorbic acid) on myocardial ischaemiareperfusion injury. The study was done using isolated rabbit?s hearts and Langendroff?s apparatus for recording myocardial contractility, heart rate, and coronary flow. Also glucose uptake by myocardial slices was estimated by glucose enzymatic kit.The present work included the following groups:*group (A): 7 rabbit?s hearts were used to study the effect of ischaemia and reperfusion on myocardial contractility, heart rate, coronary flow and glucose uptake by myocardial muscle before ischaemia, 5 minutes after ischaemia and 5,15 minutes after reperfusion.*group (B): which included 21 rabbit?s hearts divided into 3 subgroups; group (B1) to study the effects of calcium channel blocker (verapamil;0.18 mg/ml) on the tested parameters in non ischaemic control hearts. group (B2) to study the effects of angiotensin converting enzyme inhibitor (lisinopril;2.33 ug/ml) on the tested parameters in non ischaemic control heart. group (B3) to study the effects of antioxidant (ascorbic acid;0.75 mg/ml) on the tested parameters in non ischaemic control hearts.*group (C): which included 21 rabbit?s hearts subdivided into 3 subgroups; group (C1) to study the effects of 5 minutes preischaemic administration of calcium channel blocker (verapamil) on the tested parameters during ischaemia and reperfusion.group (C2) to study the effects of 5 minutes preischaemic administration of angiotensin converting enzyme inhibitor (lisinopril) on the tested parameters during ischaemia and reperfusion. group (C3) to study the effects 5 minutes preischaemic administration of antioxidant (ascorbic acid) on the tested parameters during ischaemia and reperfusion.*group (D): 21 rabbit?s hears were included in this group and subdivided into 3 subgroups; group (D1) to study the effects of administration of calcium channel blocker (verapamil) with reperfusion on the tested parameters of reperfusion. group (D2) to study the effects of administration of angiotensinconverting enzyme inhibitor (lisinopril) with reperfusion on the tested parameters of reperfusion. group (D3) to study the effects of administration of antioxidant (ascorbic acid) with reperfusion on the tested parameters of reperfusion. Results are analysed, discussed and the following could be cocluded:1.The global ischaemia decreases the myocardial contractility and heart rate but increases glucose uptake .On reperfusion, these parameters do not return to control levels.2.In control non ischaemic hearts: Verapamil is a prominant drug in decreasing myocardial contractility, heart rate and incraesing coronay flow while Ascorbic acid has an increasing effect on the rate of glucose uptake followed by Lisinopril.3. In ischemic reperfused hearts :*Lisinopril improved contractility of myocardium whether admimistered preischaemic or with reperfusion.*Lisinopril and Ascorbic acid improved heart rate whether admimistered preischemic or with reperfusion.*Verapamil improved coronary flow whether administered preischaemic or with reperfusion.4.The calcium channel blocker (Verapamil), angiotensinconverting enzyme inhibitor (Lisinopril) and antioxidant (Ascorbic acid) respectivily, significantly improve ischaemia reperfusion induced changes.