الفهرس 
Introduction
LeptinOnly 14 pages are availabe for public view
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Abstract
This study was carried out on fifty male SpargueDawley rats. Animals were randomized into five equal ten rats each. The first group (G1) was considered as control group in which animals were injected with saline solution. The other animals were injected intravenously with streptozotocin for induction of experimental diabetes mellitus and then divided into four equal groups ten rats each as the follows: (G2) was considered as control diabetic untreated group, (G3) was considered as diabetic insulin treated group, (G4) was considered as diabetic zinc treated group and (G5) was considered as diabetic insulin and zinc treated group. After the end of the experiment (4 weeks), blood (serum & whole blood) and tissue samples (liver, brain and kidney) were collected from all the animals for the analysis of: serum leptin, glucose, lipid profile and malondialdehyde in addition to enzymatic (SOD and catalase) and nonenzymatic (GSH) antioxidant enzyme activities in the whole blood and tissue malondialdehyde contents. from the obtained results it was concluded that the effect of insulin on serum glucose and leptin was not significantly differed whether injected alone or in combination with zinc. On the other hand, the effect of insulin and zinc combination was more pronounced than that of insulin alone on the other biochemical parameters. This means that insulin was the major and principal factor for correction of diabetic abnormalities and zinc as a minor not principal one. So, from this study, zinc administration in case of insulin dependent diabetes mellitus is recommended for more improvement of oxidative stress and other lipid abnormalities observed in diabetes.