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العنوان
New synthetic routes to five and six­membered heterocycles /
المؤلف
Nawar, Hagar Hussien.
هيئة الاعداد
باحث / هاجر حسين نوار
مشرف / عبدالغني علي العجمي،
مشرف / فتحي محمد عبدالعزيز الطويل
باحث / هاجر حسين نوار
الموضوع
Heterocyclic compounds. Heterocyclic compounds - Synthesis.
تاريخ النشر
2005.
عدد الصفحات
123 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/2005
مكان الإجازة
جامعة دمياط - كلية العلوم - Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

The present work resulted in the formation of functionally substituted 1,2,4­ triazoloquinoline, quinoline, chromene, coumarineimine, quinazoline, pyrazoloquinazoline and benzotriazolotriazine derivatives of potential biological importance using 5,5­dimethyl­1,3­cyclohexanedione (1), activated nitriles 2 and 3 as starting materials. It has been found that, N­(3,3­dimethyl­5­oxocyclohexylidene)benzohydr­azide (5), prepared via condensing 5,5­dimethylcyclohexane­1,3­dione (1) with benzoylhydrazine (4), reacted with the arylidenemalononitriles 2a,b,d in ethanol containing piperidine as catalyst to afford 1,5,6,7,8,9­hexahydro­8,8­dimethyl­6­oxo­ 5­aryl­2­phenyl[1,5­a]quinoline­4­carbonitriles 8a­c. Similarly, N­ (3,3­dimethyl­5­oxocyclohexylidene) benzohydrazide (5) reacted with the arylidenenitriles 2g,h in refluxing ethanol and in presence of piperidine to yield also 1, 5, 6, 7, 8, 9­hexahydro­5­ aryl­8,8­dimethyl­6­oxo­2­phenyl­[1,2,4] triazolo [1,5­a] quinoline­4­carboxamides (12a,b). Structure of the newly synthesized compounds were elucidated on the basis of their elemental analysis and spectral data as well as chemical methods.