الفهرس 
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Abstract
The present work was conducted to study the effect of estrogen replacement therapy on IL6 serum level and on other bone turnover products in experimentally induced osteoporosis in female rats. Female albino rats aged 90 days were used in this work. The animals were incubated in the laboratory with free access to water and usual diet. The animals were divided into 5 groups each consists of 8 rats. It can be concluded from the present work that : (1) Experimental osteoporosis could be induced medically by using gonadotropin releasing hormone agonist drug. (2) Estrogen deficiency has rapid effect on the skeleton producing its demineralization and porosity. (3) Osteoporsis results in the release of many bone components which find its way to the blood in a measurable amounts. (4) Blood levels of IL6 and other bone markers correlates well to the level of estrogen depletion and hence the degree of bone turnover and severity of osteoporosis. They could be used as diagnostic and follow up tools. (5) Inspite of its hazards, estrogen is still one of the best hormone replacement therapy in osteoporosis. It rapidly returns with the blood picture forwards its basal values. (6) The combination of calcium and vitamin D has an antiresorptive bone effect, which was proved in this work to be relatively similar to the low dose estrogen therapy used. (7) A combination of estrogen, calcium and vitamin D is recommended for better replacement treatment.