الفهرس 
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Abstract
This study has been planned to evaluate the neuromuscular blockade profile of pipecuronium in patients suffering from hepatic cirrhosis. Twenty patients were included in this study, divided equally into two groups, control healthy group and hepatic group submitted to operations to relieve portal hypertension.
All patients were subjected to general anaesthesia: induced with thiopenton sodium (5 mg/kg) followed by pipecuronium (0.06 mg/kg) to facilitate endotracheal intubation and maintained by N20: O2 (2:1) and halothane (0.51.0%) with 0.01 mg/ kg of pipe cur onium as maintenance relaxation doses.
Endotracheal intubation was excellently performed when T 1 ratio reached 10% and TOF ratio approximately reached 0% as traced by Datex relaxograph. The onset of action of pipecuronium, duration of clinical relaxation of bolus dose and total dose requirements were measured.
The study revealed that the onset of relaxation after injection of the bolus dose of pipecuronium was significantly longer in the hepatic than the control group. The total dose requirements showed no significant difference between the two groups of patients. Heart rate, blood pressure and oxygen saturation monitoring did not show significant variation throughout the whole procedure.
It can be conduced that pipecuronium may be a suitable muscle relaxant in patients with liver cirrhosis.