الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 108 |  |  |
| | | from | 108 | | |
Abstract
Polycystic ovarian disease (PCOD) is one of the most common causes of endocrine infertility in women. Clomiphene citrate (C.C.) is one of the initial therapies for ovulation induction in infertile women with PCqD, tlowever, the ovulation rate following CC is about 75 - 80 %. The reasons for failure to ovulate in the remaining 20% of patients are still incompletely understood. The aim of this study was to be compare between the infertile PCOD women who respond to cc. and who can not respond to identify those features which predict clomiphene response. A group of 30 infertile PCOD women (study group) and another, 30 fertile who were IUDs wearer (control group) were subJtted to clinical examination with special emphasis on age, body mass index (BMI), presence or absence of hirsutism and menstrual pattern. The hormonal profile was evaluated by estimating serum (Ltl, rsn. PRL, StlBG, IOF-L IOFBP-l). Women were monitored by transvaginal ultrasound examination. 63. Infertile PCOD women received clomiphene citrate in ascending doses (50 mgjday - 250 mgjday) from the 5th to the 9th day of the cycle after spontaneous or induced progesterone withdrawal bleeding. Patients were classified to CC. responders when CC induces follicular growth to ~ 18 mm and non responders in whom CC fails to induce ovulation up to a maximum dose 250 mgjday for 5 days for 3 successive cycles. This study showed that hirsutism and android obesity is significantly higher in PCOD women than control. Serum LIt LtljFStl ratio, total testosterone were significantly higher in peOD women while FStl, and IGFBP-l were significantly lower in PCOD women and no significant difference was noted as regards other hormone (PRL, StlBG, and IGF-l). On the other hand no statistical significant difference were noted between PCOD responders and non responders as regard clinical data or hormonal parameters, however by transvaginal ultra; sound CC-non responders showed a significant increase in ovarian volume and an increased number of ovarian follicles compared to