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Abstract Cell-mediated immunity to dermatophyte antigens, prin¬cipally trichophytin, is central to both pathogenesis of the typical tiring wormtl lesion and an acquired, relative resistance that affords partial immunity to the host. The exact form of effector tiT” cell immunity and the cellular and molecular machanisms which eliminate dermatophytes from the skin, are poorly understood, but it may involve lympho¬kine and accelerated epidermal turnover. This study is performed to clarify the role played by cell-mediated immune response in the pathogensis of dermatophytes infection, 54 patients diagnosed clinically as dermatophytosis or tenia selected from Dermatology and Venerology outpatient clinic of Mansoura University Hospitals. They were with different age, sex and clinical types of dermatophytosis. The patient were sUbjected to thorough clinical exami¬nation, the infected specimens from different mycological lesions were collected for direct examination using 30% KOH preparation, then were cultured on different mycologic media, incubated at room temperature and observed daily for growth up to 4 weeks. The growth were identified by ~acro¬scopic and microscopic examination. |