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العنوان
D.N.A flow cytometry in irradiated bladder cancer /
المؤلف
Ismail, Amal Mostafa.
هيئة الاعداد
باحث / Amal Mostafa Ismail
مشرف / Gamal El-wahidi
مشرف / Albeir Ashamallah
مشرف / Farouk A. Haggag
مشرف / Nawal M. El-Kholy
الموضوع
Bladder cancer.
تاريخ النشر
1992.
عدد الصفحات
176 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الأورام
تاريخ الإجازة
1/1/1992
مكان الإجازة
جامعة المنصورة - كلية الطب - DEPARTMENT OF NUCLEAR MEDICINE
الفهرس
Only 14 pages are availabe for public view

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Abstract

This study was performed on fourty four patients with cancer bladder, histologically proved to have transitional cell carcinoma; mean age 55 ys; 37 males and 7 females. Four cases were T1 (9.1%), 26 cases were T2 (59.1%) and 14 cases were T3 (31.8%). Histocytological grading revealed 14 cases low grade (31.8%) and 30 cases high grade (68.2%). DNA flow cytometry was performed before and three months after cessation of radiation treatment and every three months during the follow-up period. The technique used for DNA flow cytometry was the Vindelov technique for staining and the FAC scan ”Becton Dickinson” flow cytometer for analysis. DNA pattern of the fourty- four patients revealed 19 cases diploid (43.2%), 14 cases tetraploid (31.8%) and 11 cases aneuploid (25%). Correlation between DNA pattern and various clinical parameters was performed and revealed: 1- No significant correlation with the initial clinical staging before treatment, on the other hand, there was significant correlatio~ between DNA and clinical staging after irradiation with aneuploid patterns were more frequently encountered with deeply infiltrating tumors. 2- Concering DNA ploidy and tumor grade, significant correlation observed both before was and after irradiation with diploid tumors were associated with low.