الفهرس | Only 14 pages are availabe for public view |
Abstract This study was performed on fourty four patients with cancer bladder, histologically proved to have transitional cell carcinoma; mean age 55 ys; 37 males and 7 females. Four cases were T1 (9.1%), 26 cases were T2 (59.1%) and 14 cases were T3 (31.8%). Histocytological grading revealed 14 cases low grade (31.8%) and 30 cases high grade (68.2%). DNA flow cytometry was performed before and three months after cessation of radiation treatment and every three months during the follow-up period. The technique used for DNA flow cytometry was the Vindelov technique for staining and the FAC scan ”Becton Dickinson” flow cytometer for analysis. DNA pattern of the fourty- four patients revealed 19 cases diploid (43.2%), 14 cases tetraploid (31.8%) and 11 cases aneuploid (25%). Correlation between DNA pattern and various clinical parameters was performed and revealed: 1- No significant correlation with the initial clinical staging before treatment, on the other hand, there was significant correlatio~ between DNA and clinical staging after irradiation with aneuploid patterns were more frequently encountered with deeply infiltrating tumors. 2- Concering DNA ploidy and tumor grade, significant correlation observed both before was and after irradiation with diploid tumors were associated with low. |