الفهرس 
introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Progressive accumulation of iron in the body results in organ damage. Early diagnosis, followed by chelation therapy can prevent most, if not all, of the complications of iron overload. The diagnosis continues to rest upon the demonstration of excess hepatocellular iron, either hi¬sto logically or biochemically, in a liver biopsy sp acf.men , So, establishment of new techniques to quanti tate tissue iron stores non-invasive1y is desirable. In our study, we try to reevaluate the different methods of assessment of the degree of iron overload in transfusion _ dependent thalassemic patients and also to ass- ess the value of histologic examination of the skin, and correlation of its iron content with that of the serum and 1iver, We had studied 27 clrlldren, all of them belong to thalassemia as proved clinically, radiologically and laboratory incl uding haemoglobin e1ec trophoresis and haemoglobin Fde termination. Each case waS subjected to laboratory evaluation of the 1i ver function, determination of serum iron, TIBC and transferin saturation as well as liver and skin biopsy.