الفهرس 
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Abstract
This experimental study was carried out to evaluate the possible anaglesic and anti-inflammatory effects of caffeine and to determine its effect on the analgesic and anti-inflammatory activity of aspirin, tenoxicam and diclofenac. This study was carried out in rats in which inflammation was induced experimentally by subcutaneous injection of 0.1 ml of 0.5% saline solution of carrageenin in the dorsum of the right paws with an equal volwne of saline injected in the left paws. the rats were divided into 8 groups, each comprised 10 animals before giving the drugs. Group (1): Control group, received only water. Group (2): Each rat in this group, received tenoxicam 10 mg/kglday for 6 days. Group (3): Each rat in this group, received Diclofenac 3 mg/kg/day for 6 days. Group (4): Each rat in this group received Aspirin 500 mg/kglday for 6 days. Group (5): Each rat in this group received caffeine 100 rug/kg/day for 6 day. Group (6): Each rat is this group received combination of caffeine 100 rag/kg/day and aspirin 500 rag/kg/day for sucessive 6 days. Group (7): Each rat in this group received combination of caffeine 100 mg/kg/day and Diclofenac 3 rug/kg/day for sucessive 6 days. Group (8): Each rat in this group received combination of caffeine 100 mg/kg/day and tenoxicam 10 mg/kg/day for sucessive 6 days. For all groups, all drugs were given orally through a gastric tube. The following parameters were used to assess the anti inflammatory and analgesic activties of the tested drugs. 1- Paw oedema test.