الفهرس 
Introduction and Aim or the WorkOnly 14 pages are availabe for public view
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Abstract
During the course of hepatosplenic schistosomiasis, different haematologicel changes were reported; neutropenia, anaemia and thrombocytopenia either singly or in combination Attempts have been undertaken in the present work to assess the level of Granulocyte colony stimulating factor in the serum of patients with schistosomiasis and to correlate it with the different haematological findings. The present study was conducted on 81 subjects, 10 normal controls and 71 patients with schistosomiasis. According to clinical examination and laboratory investigations, patients were classified into the following groups:- Group 0: Patients with early active schistosomiasis (20 cases). Group I : Patients with hepatomegaly (18 cases). Group II: Patients with hepatosplenomegaly (12 cases). Group III: Patients with liver fibrosis (10 cases). Group IV: Patients with Liver cell failure (11 cases). All patients and control has passed thorough medical and laboratory examination in the form of urine and stool analysis, rectal snip biopsy, haematological investigations, liver functions tests, serological detection of hepatitis B and C and assessment of G-CSF level in the serum. In early active group there is no significant change in haemogram and liver functions compared to control group. With advancement of the disease there is leucopenia, anaemia, thrombocytopenia, decrease albumin level and increase in prothrombin time. Studying serum level of G-CSF revealed a significant reduction in its level in active group with no significant difference in group I, II and III. G-CSF level showed significant increase in group IV than the control. On correlating G-CSF level with the hemogram, the was significant negative correlation with WBCs, lymphocytes, granulocytes, Hb and platelets while there was insignificant negative correlation with MID, RBCs and HCT. On correlating G-CSF with liver functions parameters there was significant negative correlation with albumin and significant positive correlation with prothrombin time while there was insignificant negative correlation with bilirubin, SGOT and SGPT. It has been concluded that in active stages of schistosomiasis G-CSF may not play a role in host defense against the parasites but with advancement of the disease there is increase in G-CSF level probably to face the present neutropenia. However, it fails to correct this neutropenia. Since there is high level of G-CSF in late case of schistosomiasis only, another explanation is needed for neutropenia. Key words: (not more than ten): SLE-Microalbuminuria serum Ferritin-creatinine disease activity-SLEDAT-serumomolaity.