الفهرس 
SUBJECTS AND METHODSOnly 14 pages are availabe for public view
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Abstract
Abnormalities in pancreatic islet endocrinology are common findings in patients with chronic renal failure (Franceschini et al., 1998). Any abnormality of the highly integrated secretory pancreatic islet units may participate in the development of glucose intolerance commonly found in CRF patients (Mak, 1998). However, discripancies about, the pathogenesis of and the magnitude of the dysfunction are clear (Oroskov et al., 1992; Eidemak et al., 1995; Alvestrand, 1997). Consequently, the subject will be investigated in glucagon, insulin and somatostatin hormones as well as C-peptide, using the intravenous glucose tolerance test (Fliser et al, 1998). The present study was conducted on 30 subjects suffering from CRF. They were selected from inpatients of the Nephrology Unit, Internal Medicine Department of Mansoura University Hospital. All of them were at clinically stable state and enjoyed ambulatory life. had any associating disease(s) or factor(s) suspected to alter pancreatic islet cell endocrinology. The CRF patients were subdivided according to the therapeutic line they received into two groups. The first group comprised 15 patients who were underlying maintenance hemodialysis beside the conservative treatment. The second group comprised 15 uremic patients who received only conservative measures. At the same time, 10 healthy persons of matched age and sex were studied as a reference (control) group. Informed consent was obtained from all subjects, normal or diseased. diseased.