الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Extranodal Jow-gradeB-cell lymphomas which recapitulate the histologic features of the indolent B-cell component of Peyer’s patches were first characterized in the stomach and small intestine. Subsequently, similar tumors were identified in numerous other mucosal sites such as lung, parotids, thyroid, orbit, paranasal sinuses & nasal cavity, breast and bladder. MAL T Lymphoma was attributed to such a group of neoplasms that specifically arise from the marginal zone of lymphoid tissue acquired in the course of a prolonged chronic inflammatory disorder, often with an autoimmune component stimulating DNA synthesis. In the recent REAL IWHO classifications, MALT lymphomas are included in the indolent B-cell marginal zone neoplasms as a separate clinico-pathologic entity, distinct from other aggressive extranodal NHL. Strict criteria for diagnosis include small bland B-cells (centrocytic-like, monocytoid, lymphocytic, lymphoplasmacytic), reactive’ follicles, chronic inflammation and lymphoepitheliallesions. Diagnostic phenotype is as follows: CD:w+ , IgM+ , CD::;-, CD 10-, CDn¬and CD43-. Genotyping shows trisomy 3 and t (11; 18) in 6()(~;() of cases.