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Abstract Preterrn labor (delivery before 37 weeks gestation) is considered the most important cause of perinatal mortality and morbidity including mental and physical disabilities. The incidence of preterrn labor in developed countries such as United. States of America •<lIld Europian countries varies between 6 and 7% according to WIlO statistics. As it correlates with the socioeconomic standerd so, the incidence of pretenn labor increases much in developing countties and areas of low socioeconomic standards. According to Egyptian Ministry of Health, the incidence of preterm lahar in Egypt is about 15.8% in 1985. As the causes of preterm labor are still unknown clearly uptill now, so the prevention of preterrn labor forms a great problem facing the obstetricians. There were many researches which are done to determine the women at high risk of preterm labor. These include: =>Cervical assessment either by transvaginal sonography or digital palpation. =>The presence of fibronedine in cervico-vaginal secretions. => Uterine activity monitoring. =>Lastely the biochemical mediators. |