الفهرس 
Review of literatureOnly 14 pages are availabe for public view
 |  | from | 179 |  |  |
| | | from | 179 | | |
Abstract
Severe head injury is one of the major causes of death, king fourth in most western countries, behind circulatory, plastic and respiratory diseases. This has been powerful ulus for both neurotrauma research and clinical trials. The ophysiology of neurotrauma is complex and the mechanisms only partially understood. The major clinical focus when aging patients with severe head injury, is to prevent secondary Its starting from the time of the injury. This applies not only to obvious mechanisms, like maintaining cerebral perfusion sure, but also to more subtle mechanisms such as increased oexcitation for example due to occult seizures, cytokine iated damage such as may occur after pyrexia or altered brovascular reactivity due to modified posttraumatic reactions microvessels to endothelin, nitric oxide or endorphins.