الفهرس | Only 14 pages are availabe for public view |
Abstract Wound healing is a process that has many complications, probably one of the most important of these complications is the development of hypertrophic scars and keloids. Keloid repccsenC a ftbroblastic response to injury in excess of that appropriate for repair of the injury. Keloid formation appears to be a perversion of normal wound healing, in which the rate of collagen biosynthesis is increased. The fibroblastic response, which lasts only two to three weeks in normal wound healing, may continue for months in keloids. Subsequent stages in normal wound healing are also greatly prolonged in keloid formation. Clinically keloids present themselves as single or multiple, firm nodules or markedly elevated plaques with variable sizes. A hypertrophic scar is a similar lesion to keloid, but will in time undergo some degree of resolution. Hypertrophic scars are confined with the boundaries of the wound in contrast with keloids which have claw like prolongations that extend beyond the limits of the injury. In the vast majority of cases trauma has been the main ; if not, the only provoking factor in keloid formation. Trauma may be in any form such as operative wounds and incisions, tattoos, insect bites, vaccination and above all burns and scalds. In many instances, however, a preceding injury cannot be identified. The tendency to develop keloids depends upon a number of factors, including race, age, familial tendency, location on the body and type of injury. |