الفهرس 
INTRODUCTION&Aim of the workOnly 14 pages are availabe for public view
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Abstract
Nephrotic syndrome is the most prevalent glomerular disease in children accounts for 90% of childhood nephrosis. MCNS represents more than 85%of cases with peak incidence between the age of 2 and 6 years. The etiology of PNS still obscure; although T-cell dysfunction has been claimed. The present study was carried out to clarify the role of IL-12 and IL-13 in pathogenesis of PNS. This study was carried out from January 2000 to August 2000, where 20 patients were included during disease activity, 15 patients were included during remission and 10 healthy children of matched age and sex were included as a control group. The patients with PNS either in remission or in disease activity were selected from patients of out patient clinic of pediatric Nephrology Unit or patients admitted to Mansoura University Children Hospital. The study groups were subjected to the routine investigation of NS, they also subjected to estimation of serum s1L-12 and s1L-13 and their production in supernatant from cultured lymphocyte. The results ofthe study revealed: I. A significantly increased serum levels of IL-12 in patients during disease activity when compared either to control group or patients during.