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Abstract This prospective study was designed to evaluate the effect of different aesthetics on release of free radicals in traumatized and non traumatized patients . Eighty patients of either sex , aged 20-50 years ,were classified into two ain groups according to presence or absence of trauma . .Trauma group:- This group consistes of forty patients with fracture femur, other fractures and ft tissue trauma admitted to Mansoura Emergency Hospital. .Non trauma group (Control group) :- Consistes of forty patients admitted to Mansoura University Hospital for repair f incisional hernia. Patients of each group were anaesthetised by halothane, isoflurane , ketamine and ropofol as follow :- Halothane- nitrous oxide relaxant group (1 0 patients) . Isoflurane- nitrous oxide relaxant group (10 patients) . Ketamine- fentanyl relaxant group (10 patients) . propofol- fentanyl relaxant group (10 patients) . All Patients were premedicated with 0.05 mg/kg midazolam, and atropine 0.02 IIlgkg intravenously after arrival to the preoperative area. Blood samples were withdrawn from the patients before induction of anathesia as basal samples, then after nduction of anathesia by 15 min. , then after start of surgery by 30 minutes and after xtubatian by 30 minutes in the recovery room. Previous samples were analyzed to 105 Summary This prospective study was designed to evaluate the effect of different aesthetics on release of free radicals in traumatized and non traumatized patients . Eighty patients of either sex , aged 20-50 years ,were classified into two ain groups according to presence or absence of trauma . .Trauma group:- This group consistes of forty patients with fracture femur, other fractures and ft tissue trauma admitted to Mansoura Emergency Hospital. .Non trauma group (Control group) :- Consistes of forty patients admitted to Mansoura University Hospital for repair f incisional hernia. Patients of each group were anaesthetised by halothane, isoflurane , ketamine and ropofol as follow :- Halothane- nitrous oxide relaxant group (1 0 patients) . Isoflurane- nitrous oxide relaxant group (10 patients) . Ketamine- fentanyl relaxant group (10 patients) . propofol- fentanyl relaxant group (10 patients) . All Patients were premedicated with 0.05 mg/kg midazolam, and atropine 0.02 IIlgkg intravenously after arrival to the preoperative area. Blood samples were withdrawn from the patients before induction of anathesia as basal samples, then after nduction of anathesia by 15 min. , then after start of surgery by 30 minutes and after xtubatian by 30 minutes in the recovery room. |