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Abstract Helicobacter pylori was suggested to have a causative role in rosacea, and its eradication was said to be associated with improvement ofrosacea. To evaluate this suggested role, this study was conducted on 54 rosacea patients and 26 age and sex matched control subjects. All patients were subjected to thorough history taking with stress on factors that could flare up the rosacea. Then rosacea severity was graded according to Henderson et a I (1995). Also, the patients were examined for manifestations of ocular rosacea. Blood samples were taken from patients and controls to detect serum anti-//. pylori IgG antibodies, IL-2 and IL-4. Gastroduodenscopy was done for 28 patients, and antral and duodenal biopsies were taken. These biopsies were subjected to direct Gram smear, direct urease test and culture. All patients were given anti-//. pylori treatment in the form of Amoxacillin and Metronidazole for 10 days. Only 26 patients completed the follow up period. They wrere reassessed clinically at the end of treatment, 1 month and 6 months after treatment. Another blood sample was taken to detect anti-// pylori antibodies at the end of follow up period. Rosacea was found to be highly associated with female sex, and its occurrence increases with age till the 5U decade then decline. The most common presenting symptom of rosacea is burning sensation in females, while most males were asymptomatic. Rosacea had |