الفهرس 
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Abstract
The controlled study was carried out on forty five patients of either sex with age ranging between 20-60 years, they were submitted for brain tumour resection. They were randomly allocated into three equal groups: each of comprised of 15 patients. Anaesthesia was induced with a sleeping dose of thiopentone and tracheal intubation was facilitated with suxamethonium Img/Kg. Muscle relaxation was done by the use of pipecuronium in an initial dose of 0.7 mg/Kg and incremental dose of 1/5 of the initial dose as needed. Patients were randomly allocated into three equal groups according to the type of maintenance of anaesthesia: first group was maintained by isofiurane 1%, second group was maintained by thiopentone-fentanyl infusions using a disending dosing schedule; for thiopentone by 10 mg/Kg/hr in the 1st hr, 8mg/Kg/hr in the 2nd hr, 6 mg/Kg/hr for 3rd hr onward, 6 mg/Kg/hr closure dose and zero dose for scalp. Whereas fentanyl was maintained as infusion by 1 (ig/Kg/hr in the 1st hr, 0.5 jig/Kg/hr in the 2nd hr, 0.25 jig/Kg/hr from 3rd hr onward, 0.25 ]ug/Kg/hr closure dose and zero dose for scalp. Third group was maintained by thiopentone-midazolam, thiopentone was used by the same previous regimen and midazolam was infused by 50 )ig/Kg/hr in the 1st hr, 30 jig/Kg/hr in the