الفهرس 
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Abstract
The effect of phenobarbital and rifampin, the widely used nticonvulsant and antituberculous drugs respectively, has been studied on the rat livers. The effect of these drugs on glycogen ncentration has been biochemically determined and the morphological changes has been studied both light and electron microscopes. To complete my experiments, 24 rats have been used in 2 experiments. In the first riment, 12 rats were used from which 6 rats received intraperitoneal injections of 80 mg/kg obarbital for 5 days, 3 rats received intraperitoneal injection of saline for the same period lrats received no treatment. In the second experiment, 6 rats received 400 mg/kg rifampin for 5 da s through an intragastric route, 3 rats receiVed equivalent amounts of saline daily gh an intragastric route, and 3 rats received nothing. All rats had free access to food and dUring the experiment and they were sacrificed on the 6th day after initiation of treatment by decapitation. phenobarbital drug caused a decrease in liver glycogen concentration which was ieally determined. Variation in glycogen levels between individual rats was found, and elated with the reported individual variations in expression of P450 after phenobarbital as both has intimate relation to SER. gen distribution was studied after phenobarbital administration in relation to lobular centrilobular hepatocytes showed homogenous decrease in glycogen content, and the icles appeared close to vesicles of SER. In periportal areas, there was heterogenous Some hepatocytes showed a marked decrease in glycogen content with a pattern of centrilobular hepatocytes; others had large clumps of firmly packed glycogen .