الفهرس 
INTRODUCTION and Aim of the work.Only 14 pages are availabe for public view
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Abstract
Antineutrophil cyroplasmic antibodies (ANCA) are autoantibodies directed against Lysosomal enzymes of human neutrophil and monocytes. Aim of our study to determine the correlation between the occurrence of ANCA and their antigens in sera of patients with connective tissue diseases and study the relationship between perinuclear and cytoplasmic ANCA with clinical and laboratory findings in those patients. Also, investigated the association between human leucoytic antigens (HLA) and ANCA. 20 patients with rheumatoid arthritis (RA), 20 patients with systemic lupus erythematosus (SLE), 10 patients with systemic sclerosis (SSC) and 10 patients with vasculitis. We determined HLA typing class I and class II by using the microcytotoxicity test while tested ANCA by ELISA. Results : P-ANCA concentrations were significantly higher in RA patients than control. P-ANCA concentrations were significantly higher in SLE than control. P-ANCA concentrations were significantly higher in SSC patients than control. While, C-ANCA concentrations were significantly higher in wegener’s granulomatosis (WG) patients than control. Conclusion: 1-In RA, the prevalence of P-ANCA positivity is 60% and it has prognostic value and helping making early decision of more specific therapy for RA patients. Increase p-ANCA titer is more associated with HLA-DR4 antigens which have a prognostic value in RA. 2- In SLE, the prevalence of P-ANCA positivity is 75% and increase P-ANCA titer is associated with renal affection and photosensitivity. 3-In systemic sclerosis, the prevalence of P-ANCA positivity is 60% and increase P-ANCA titer is associated with renal affection and HLA-DR3 in systemic sclerosis patients. 4-In WG, the prevalence of C-ANCA positivity is 80% while P-ANCA is not detected in these patients. Moreover, in Burger’s disease patients, the prevatence of P-ANCA positivity is 20% while c-ANCA is not detected in these patients.