الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of the present work was to assess the efficacy & safety of nandrolone decanuate & low dose EPO in comparison with the use of low dose EPO alone for treatment of anemia in CRF patients on regular hemodialysis.Thirty anemic patients who had adequate hemodialysis and nutrition were treated with iron saccharate .The first group of patients was allocated into a low dose EPO schedule ,the second group of patients was given the same low dose EPO combined with nandrolone decanuate ,the third one was ranked as a control one.All patients were followed up for 6 months .Our results showed a significant rise of both hemoglobin and hematocrit in all groups at the end of the study Although the mean of rise of hemoglobin and hematocrit was higher in the second group but this rise did not attain a statistical significance Because of the androgen related side effects 4 patients were withdrawn from androgen therapy and continued low dose EPO with subsequent improvement of adverse events especially hirsutism or menstrual disorders.So provision of adequate hemodialysis and nutritional status& parenteral iron supply is important for treating the anemia associated with hemodialysis.Nandrolone decanoate is hazardous. Low dose EPO is not effective to achieve the targeted hemoglobin for patients on hemodialysis. |