الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: Much of the morbidity and mortality associated with diabetes mellitus predominantly reflects its deleterious effects on microcirculation and macrocirculation. VEGFs are endogenously produced vascular cytokines which have been shown to be fundamental regulators of cell signaling of angiogenesis which has been shown to be essential for development and progression of diabetic vascular complications. Aim of work: The aim of this work is to study the relationship between vascular endothelial growth factor as the strongest known angiogenic factor and different micro- and macrovascular complications in diabetic patients. Methods: The study comprised 113 patients of type 2 diabetes mellitus, 60 were males and 53 were females with different micro- and macro-vascular complications with age ranging from 35 to 75 years. They were compared to 30 healthy individuals as a control group. Results: There were highly significant increases in the serum levels of vascular endothelial growth factor (VEGF) in the diabetic patients compared to non diabetic healthy individuals. Serum VEGF levels were found significantly higher in diabetic patients with different micro- and macrovascular complications compared to non complicated diabetic and non diabetic healthy individuals. Marked reduction of the elevated levels of serum VEGF was observed with proper glycemic control of the diabetic patients. Conclusion: We can conclude that serum VEGF is significantly increased in diabetic patients especially with micro- and macrovascular complications and this elevation of VEGF was reduced in uncontrolled diabetic patients with proper glycemic control.