الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a chronic inflammatory hyperproliferative disease of the skin affecting 1-2% of the population This study was conducted on 59 patients, they were allocated into two groups, group A and group B. group A, included 34 patient (17 male, 7 female), they recieved PUVA 3 times weekly and group B, included 25 patient (19 male, 6 female), they recieved UVB 3 times weekly. The study was conducted over a period of 12 weeks. For assessment of clinical severity of psoriasis and evaluation of treatment, PASI score was performed for every patient at the beginning of treatment, after 6 weeks then after 12 weeks. No significant difference was found in the overall efficacy of the regimens, however PUVA was more liable to induce complete remission. Histopthological examination and Bcl-2 immunostaining using mouse IgG1 monoclonal antibody were performed before and after treatment. Immunohistochemical examination showed a significantly lower Bcl-2 expression in psoriatic lesions in comparison to normal skin and non lesional skin. The effect of UV irradiation on Bcl-2 expression in psoriasis was variable, it resulted in downregulation of Bcl-2 expression in some specimens, and its upregulation others.