الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
BACKGROUND: The majority of patients with hepatocellular carcinoma (HCC) have coexisting cirrhosis or chronic hepatitis, often complicated by diabetes mellitus. In the current study, we evaluated the impact of diabetes mellitus on the prognosis of patients with HCC. METHODS: Among 133 patients with HCC who had been diagnosed and treated between 2001 and 2003, survival was compared between those patients with and those patients without diabetes mellitus. RESULTS: Forty six patients had diabetes mellitus. There was no significant difference with regard to patient characteristics (i.e., age, gender) or tumour site and size between those patients with and those patients without diabetes mellitus (only number of focal lesions). No differences were observed in survival between patients with diabetes mellitus and patients without it. There was poor prognosis with increasing the number of the lesions and increasing tumour size to >3 cm (P = 0.01). Diabetes may be an independent risk factor for developing HCC in patients with chronic HCV. On multivariate analysis, diabetes mellitus was found to be an independent factor predicting lower survival after treatment (P = 0.026) among patients with a solitary HCC lesion measuring < or = 3 cm in greatest dimension. CONCLUSION: This study confirmed that diabetes may be an independent risk factor for developing HCC in patients with chronic hepatitis C. Decreased occurrence of HCC might be achieved, if diabetes could be properly controlled. Child-Pough grade, size of the largest tumour, therapy and the type of viral hepatitis infection were found to be significant factors affecting survival.